![]() ![]() Leg macro- and microvascular flow was assessed via ultrasound and anabolic signalling by immunoblotting. Four muscle biopsies were taken, and muscle protein turnover was quantified via incorporation of 13 C6 phenylalanine and arteriovenous balance kinetics, using mass spectrometry. infusions of octreotide and Vamin 14 (±infusions of GLP-1). Baseline measures were taken over 3 hr, prior to a 3 hr postprandial insulin (~30 mIU ml-1 ) and glucose (7-7.5 mM) clamp, alongside I.V. BackgroundDespite its known insulin-independent effects, glucagon-like peptide-1 (GLP-1) role in muscle protein turnover has not been explored under fed-state conditions or in the context of older age, when declines in insulin sensitivity and protein anabolism, as well as losses of muscle mass and function, occur.MethodsEight older-aged men (71 ± 1 year, mean ± SEM) were studied in a crossover trial.
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